Dynabol (Methandrostenolone)

02 Details

Dynabol

 (Methandrostenolone)

Decabol

(Nandrolone Decanoate)

Decanoato de nandrolona; Nandrolon-dekanoát; Nandrolone, décanoate de; Nandroloni decanoas; Nandrolonu dekanonian; Nortestosterone Decanoate; Nortestosterone Decylate. 3-Oxoestr-4-en-17β-yl decanoate; 17β-Hydroxyestr-4-en-3-one decanoate. Нандролона Деканоат

C28H44O3 = 428.6.

CAS — 360-70-3.

ATC — A14AB01; S01XA11.

ATC Vet — QA14AB01; QS01XA11.

Pharmacopoeias. In Eur.(see p.vii) and US.

Ph. Eur. 6.2(Nandrolone Decanoate). A white or almost white, crystalline powder. M.p. 34°to 38°. Practically insoluble in water; very soluble in alcohol and in dichloromethane. Store under nitrogen at 2°to 8°. Protect from light.

USP 31(Nandrolone Decanoate). A white to creamy-white fine crystalline powder, odourless or may have a slight odour. Practically insoluble in water; soluble in alcohol, in acetone, in chloroform, and in vegetable oils. Store at 2°to 8°in airtight containers. Protect from light.

Decabol contains:300mg

• 300 mg / ml Nandrolone Decanoate

 

Pharmacologic Category

Androgen

Uses and Dosing

Anabolic agents have been used for reversing catabolic conditions, promoting weight gain, increasing muscling, and stimulating erythropoiesis

Osteoporosis and breast cancer. Doses of nandrolone decanoate 50 to 100 mg once every 3 to 4 weeks have been used as an anabolic after debilitating illness, for postmenopausal osteoporosis, and for postmenopausal metastatic breast carcinoma.

Anemia. Doses of between 50 and 200 mg weekly have been suggested for the treatment of anaemia of chronic renal failure, and doses of 50 to 150 mg weekly for aplastic anaemia.

Cachexia. Nandrolone increased lean body-mass in patients with HIV-associated wasting and was found to have greater effect than testosterone on body-weight and BMI but a similar effect on lean body-mass. Nandrolone has also increased lean body-mass in patients with end-stage renal failure undergoing dialysis.

Although caution is generally advised with the use of androgenic and anabolic steroids in patients with renal impairment a study of nandrolone given for 3 months to patients with pre-dialysis chronic renal impairment found that lean body-mass increased without fluid retention or adverse effect on renal function or serum-lipids.

In these reports, intramuscular doses of nandrolone decanoate have ranged from 100 mg once every 2 weeks up to 600 mg weekly, and treatment has generally been given for 12 to 24 weeks.

Male contraception. Preliminary findings showed that nandrolone suppressed spermatogenesis, suggesting potential as a male contraceptive (p.2070), but later studies seem to have favored other androgens.

 

Administration

Deep intramuscular

 

Storage/Stability

 

Store in a tightly sealed container, protected from light, and at room temperature.

Stability of compounded formulations has not been evaluated.

 

Contraindications

Hypersensitivity to the drug, prostate cancer, male breast cancer, breast carcinoma in women with hypercalcemia, CPI, severe atherosclerosis, nephrotic syndrome, acute and chronic liver disease, including alcoholic nephritis, pregnancy, lactation.

Pregnancy Risk Factor

X

Category X: Studies in animals or human beings have demonstrated fetal abnormalities, or there is evidence of fetal risk based on human experience, or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

 

Pregnancy Considerations

Use is contraindicated in women who are or may become pregnant; masculinization of the fetus has been reported.

Lactation

Excretion in breast milk unknown/not recommended

Breast-Feeding Considerations

It is not known if nandrolone is excreted in breast milk. Due to the potential for serious adverse reactions in the nursing infant, breast-feeding is not recommended.
Adverse Effects and Precautions

As for androgens and anabolic steroids in general.

In women – virilizing symptoms, inhibition of ovarian function, menstrual disorders, and hypercalcemia.

In men: in prepubertal – virilization symptoms, skin hyperpigmentation idiopathic retention
or stopping the growth (calcification of epiphyseal growth zones of tubular bones); during post-puberty.

Bladder irritation, gynecomastia, priapism; the elderly – hypertrophy and / or prostatic carcinoma.

Progression of atherosclerosis, peripheral edema, impaired liver function with jaundice, changes in leukocytes, long tubular bones pain, hypocoagulation prone to bleeding.

Effects on the liver. Intrahepatic cholestasis occurred in a patient receiving nandrolone cyclohexylpropionate. A non-C17-alkylated steroid and long-term cholestasis.

Porphyria. Nandrolone has been associated with acute attacks of porphyria and is considered unsafe in porphyric patients.

At the first signs of virilization of patients (deepening of the voice, hirsutism, acne, clitoromegalie) administration should be stopped to avoid irreversible changes.

Suppression of coagulation factor in plasma may occur (factors II, VII, IX and X and prothrombin time increased). A systematic control the lipids and cholesterol. Use in pediatric population should be done by an experienced specialist to avoid premature calcification of epiphyseal bones.
Interactions

Interactions reported include: Glucocorticoids, mineralocorticoids, corticotropin preparations containing sodium rich foods enhances sodium retention in the body, increase the risk of developing edema, acne eruptions intensify.

Increases the action of antiplatelet, anticoagulant, insulin and oral antidiabetics, decreases action somatotropin and its derivatives.
Dosage forms

Nandrolone decanoate; oily injectable solution: 50 mg, 200 mg or 300 mg.

 

Mechanism of Action

 

Anabolic steroid. Nandrolone is a derivative of testosterone used as an anabolic agent. Anabolic agents are designed to maximize anabolic effects while minimizing androgenic action.

Pharmacodynamics/Kinetics

Following intramuscular dose of 100 mg peak plasma concentration is achieved over 1-3 weeks.

Metabolism: Hepatic (Liver)

Elimination: Urine (90%) and Feces (6%)